Sandostatin

Sandostatin® LAR Depot:
A Long History of Control in Acromegaly

For over 10 years, Sandostatin® LAR Depot (octreotide acetate for injectable suspension) has demonstrated strong evidence and has been a trusted medical therapy.1,2

Sandostatin® is a type of medical treatment for acromegaly called a somatostatin analogue3

  • Sandostatin® LAR Depot works by reducing both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels3
  • In addition, Sandostatin® is the #1 prescribed somatostatin analogue in the world*1

Control you can trust

Sandostatin® offers you:

  • Confidence and reliability of over 5 million doses of Sandostatin® LAR Depot administered worldwide*2
  • More than 20 years of strong evidence, established through2-4
    • Over 800,000 patient-years of experience2
    • Over 6000 published articles2,4
    • Over 600 clinical trials2,4

*For all approved indications.

Combined use of immediate-release Sandostatin® Injection and Sandostatin® LAR Depot for all approved indications.

Includes both ongoing and completed trials for all approved indications.

Remember to always report any symptoms as accurately as possible and discuss these with your doctor. This will ensure that you get the best dosage for your treatment.

INDICATIONS AND USAGE

Sandostatin® LAR Depot (octreotide acetate for injectable suspension) is a prescription medicine indicated for patients in whom initial treatment with immediate release Sandostatin® (octreotide acetate) Injection has been shown to be effective and tolerated for:

  • Long-term maintenance therapy in acromegalic patients who have had inadequate response to surgery and/or radiotherapy or for whom surgery and/or radiotherapy is not an option (the goal of treatment in acromegaly is to reduce GH and IGF-1 levels to normal).
  • Long-term treatment of the severe diarrhea and flushing episodes associated with metastatic carcinoid tumors.
  • Long-term treatment of the profuse watery diarrhea associated with VIP-secreting tumors

In patients with carcinoid syndrome and VIPomas, the effect of Sandostatin Injection and Sandostatin LAR Depot on tumor size, rate of growth and development of metastases has not been determined.

IMPORTANT SAFETY INFORMATION

Warnings and precautions: Treatment with Sandostatin LAR Depot may affect gallbladder function, sugar metabolism, thyroid and heart function, and nutritional absorption, which may require monitoring by your doctor.

Before taking Sandostatin LAR Depot: Tell your doctor if you have a history of heart disease or are taking other medications, including: cyclosporine, insulin, oral hypoglycemic agents, beta-blockers, and bromocriptine.

Common side effects: Most patients experience side effects at some time. Some common side effects you may experience include:

  • Acromegaly: diarrhea, gallstones, abdominal pain, and flatulence
  • Carcinoid tumors: back pain, fatigue, headache, abdominal pain, nausea, and dizziness

Other information: Patients with carcinoids tumors and VIPomas should adhere closely to their scheduled return visits for reinjection in order to minimize exacerbation of symptoms. Patients with acromegaly should adhere to their return visit schedule to help assure steady control of GH and IGF-1 levels.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

References

(1) IMS Report to Novartis Pharmaceuticals Corporation; 2007.

(2) Data on file. Novartis Pharmaceuticals Corporation.

(3) Sandostatin® LAR Depot [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2010.

(4) PubMed [database online]. National Center for Biotechnology Information. Available at: http://www.ncbi.nlm.nih.gov/sites/gquery?term=sandostatin. Accessed March 19, 2009.

Important Safety Information

FOR ACROMEGALY
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